Course readings.

SES #	TOPICS	READINGS
1	Introduction: The Aging Brain, Corkin Lecture	Squire, L. "Memory systems of the brain: A brief history and current perspective." Neurobiology of Learning and Memory 82 (2004): 171-177. Hof, P. R., and J. H. Morrison. "The aging brain (includes Alzheimer's): morphomolecular senescence of cortical circuits." Trends in Neurosci 27 (2004): 607-613. Reference Piguet, O., and S. Corkin. "The aging brain." In Learning and the Brain: An Encyclopedia. Edited by S. Feinstein. Westport, CT: Greenwood Publishing Group. (In press)
2	Imaging the Aging and Demented Brain	Jack, C. R., B. A. Shiung, J. L. Gunter, et al. "Comparison of different MRI brain atrophy rate measures with clinical disease progression in AD." Neurology 62 (2004): 591-600. Karas, G. B., O. Scheltens, S. A. R. B. Rombouts, et al. "Global and local gray matter loss in mild cognitive impairment and Alzheimer's disease." NeuroImage 23 (2004): 708-716. Salat, D., D. Tuch, D. Greve, et al. "Age-related alterations in white matter microstructure measured by diffusion tensor imaging." Neurobiology of Aging. (In press) Den, Heijer T., M. Oudkerk, L. J. Launder, et al. "Hippocampal, amygdalar, and global brain atrophy in different apolipoprotein E genotypes." Neurology 59 (2002): 746-748. Klunk, W., H. Engler, A. Nordberg, et al. "Imaging brain amyloid in Alzheimer's disease with Pittsburgh compound-B." Annals of Neurology 55 (2004): 306-319. Background Petersen, R. "Mild cognitive impairment as a diagnostic entity." Journal of Internal Medicine 256 (2004): 183-194.
3	Working Memory in Aging and Alzheimer's	Bowles, R. P., and T. A. Salthouse. "Assessing the age-related effects of proactive interference on working memory tasks using the Rasch model." Psychology and Aging 18 (2003): 608-615. Lamar, M., D. M. Yousem, and S. M. Resnick. "Age differences in orbitofrontal activation: an fMRI investigation of delayed match and nonmatch to sample." Neuroimage 21 (2004): 1368-1376. Park, D. C., R. C. Welsh, C. Marshuetz, et al. "Working memory for complex scenes: age differences in frontal and hippocampal activations." JOCN 15 (2003): 1122-1134. Cabeza, R., S. M. Daselaar, F. Dolcos, et al. "Task-independent and taskspecific age effects on brain activity during working memory, visual attention and episodic retrieval." Cereb Cortex 14 (2004): 364-375. Baddeley, A. D., S. Bressi, Sala S. Della, R. Logie R, and H. Spinnler. "The decline of working memory in Alzheimer's disease. A longitudinal study." Brain 114 (1991): 2521-2542. Background Salthouse, T. "The aging of working memory." Neuropsychology 8 (1994): 353-543.
4	Recollection and Familiarity in Healthy Aging	Naveh-Benjamin, M., J. Guez, A. Kilb, and S. Reedy S. "The associative memory deficit of older adults: further support using face-name associations." Psychology and Aging 19 (2004): 541-546. Glisky, E. L., S. R. Rubin, and P. S. Davidson. "Source memory in older adults: an encoding or retrieval problem?" JEP: LMC 27 (2001): 1131-1146. Castel, A. D., and F. I. Craik. "The effects of aging and divided attention on memory for item and associative information." Psychology and Aging 18 (2003): 873-885. Clarys, D., M. Isingrini, and K. Gana. "Mediators of age-related differences in recollective experience in recognition memory." Acta Psychologica 109 (2002): 315-329. Vandenbroucke, M. W., R. Goekoop, E. J. Duschek, et al. "Interindividual differences of medial temporal lobe activation during encoding in an elderly population studied by fMRI." Neuroimage 21 (2004): 173-180. Background Naveh-Benjamin, M. "Effects of divided attention on encoding and retrieval processes: assessment of attentional costs and a componential analysis." JEP: LMC 26 (2000): 1170-1187.
5	Emotional Memory in Aging and Age-related Disease	Leigland, L., L. Schulz, and J. Janowsky. "Age related changes in emotional memory." Neurobiology of Aging 25 (2004): 1117-1124. Kensinger, E., A. Anderson, J. Growdon, and S. Corkin. "Effects of Alzheimer disease on memory for verbal emotional information." Neuropsychologia 42 (2004): 791-800. Denburg, N., T. Buchanan, D. Tranel, and R. Adolphs. "Evidence for preserved emotional memory in normal older persons." Emotion 3 (2003): 239-253. Charles, S. T., M. Mather, and L. Cstensen. "Aging and emotional memory: The forgettable nature of negative images for older adults." JEP: General 132 (2003): 310-324. Kensinger, E. "Memory for contextual details: Effects of emotion and aging." Psychology and Aging. (In press)
6	Midterm Exam (1 Hour) Implicit Memory	Woodruff-Pak, D. S., and R. G. Finkbiner. "Larger nondeclarative than declarative deficits in learning and memory in human aging." Psychol Aging 10, no. 3 (1995): 416-26. Light, L. L., and A. Singh. "Implicit and explicit memory in young and older adults." J Exp Psychol Learn Mem Cogn 13, no. 4 (1987): 531-41.
7	Alzheimer's Disease: Natural History, Genetics, and Pathophysiology (Guest Lecture: Michael C. Irizarry, M. D., Alzheimer Disease Research Unit, Massachusetts General Hospital)	Background Ingelsson, M., H. Fukumoto, K. L. Newell, J. H. Growdon, E. T. Hedley-Whyte, M. P. Frosch, M. S. Albert, B. T. Hyman, and M. C. Irizarry. "Early Aß accumulation and progressive synaptic loss, gliosis, and tangle formation in AD brain." Neurology 62 (2004): 925-31.
8	Alzheimer's Disease: Early Molecular Biology, Genetics, Animal Models	Nestor, P. J., P. Scheltens, and J. R. Hodges. "Advances in the early detection of Alzheimer's disease." Nature Medicine 10 Suppl. (2004): S34-S41. Melov, S. "Modeling mitochondrial function in aging neurons." Trends in Neurosci 27 (2004): 601-606. Mattson, M. P., S. Maudsley, and B. Martin. "BDNF and 5-HT: a dynamic duo in age-related neuronal plasticity and neurodegenerative disorders." Trends in Neurosci 27 (2004): 589-594. Toescu, E. C., A. Verkhrasky, and P. W. Landfield. "Ca++ regulation and gene expression in normal brain aging." Trends in Neurosci 27 (2004): 614-620.
9	Alzheimer's Disease (cont.)	Glenner, G. "Amyloid ß protein and the basis for Alzheimer's disease." In Progress in Clinical and Biological Research. Edited by N. Back, G. Brewer, V. Eijsvoogel, R. Grover, K. Hirschhorn, et al. Vol. 317, Alzheimer's Disease and Related Disorders, edited by K. Iqbal, H. Wisniewski, and B. Winblad. New York, NY: Alan R. Liss, Inc., 1989, pp. 857-868. Schenk, D., R. Barbour, W. Dunn, et al. "Immunization with amyloid-ß attenuates Alzheimer-disease-like pathology in the PDAPP mouse." Nature 400, no. 6740 (1999): 173-7. Selkoe, D. J., and D. Schenk. "Alzheimer's Disease: Molecular understanding predicts amyloid-based therapeutics." Annu Rev Pharmacol Toxicol 43 (2003): 545-584.
10	Alzheimer's Disease: ß-amyloid and LTP, Distribution of AD Target Tissues, Tauopathies	Teter, B. and C. E. Finch. "Caliban's heritance and the genetics of neuronal aging." Trends in Neurosci 27 (2004): 627-632. Citron, M., T. Oltersdorf, C. Haass, et al. "Mutation of the ß-amyloid precursor protein in familial Alzheimer's disease increases bprotein production." Nature 360 (1992): 672-4. Schenk, D., M. Hagen, and P. Seubert. "Current progress in ß-amyloid immunotherapy." Curr Opin Immunol 16 (2004): 599-606. Hock, C., U. Konietzko, J. R. Streffer, et al. "Antibodies against betaamyloid slow cognitive decline in Alzheimer's disease." Neuron 38, no. 4 (2003): 547-54. Blanchard, B. J., A. Chen, L. M. Rozeboom, K. A. Stafford, P. Weigele, and V. M. Ingram. "Efficient reversal of Alzheimer's disease fibril formation and elimination of neurotoxicity by a small molecule." Proc Natl Acad Sci U S A 101 (2004): 14326-32. Ye, C., D. M. Walsh, D. J. Selkoe, and D. M. Hartley. "Amyloid ß-protein induced electrophysiological changes are dependent on aggregation state: N-methyl-D-aspartate (NMDA) versus non-NMDA receptor/channel activation." Neurosci Letters 366 (2004): 320-325.
11	Parkinson's Disease/Huntington's Disease: Molecular, Genetic Mechanisms, Memory	Gilbert, B., S. Belleville, L. Bherer, and S. Chouinard. "Study of verbal working memory in patients with Parkinson's disease." Neuropsychology 19 (2005): 106-14. Ross, C. A., and M. A. Poirier. "Protein Aggregation and neurodegenerative disease." Nature Medicine 10 Suppl. (2004): S10-S17. Lemiere, J., M. Decruyenaere, G. Evers-Kiebooms, et al. "Cognitive changes in patients with Huntington's disease (HD) and asymptomatic carriers of the HD mutation-a longitudinal followup study." J Neurol 251 (2004): 935-42.
12	Parkinson's Disease/Huntington's Disease: Molecular, Genetic Mechanisms, Memory (cont.)	Bossy-Wetzel, E., R. Schwarzenbacher, and S. A. Lipton. "Molecular pathways to neurodegeneration." Nature Medicine 10 Suppl. (2004): S2-S9. Castner, S., and P. Goldman-Rakic P. "Enhancement of working memory in aged monkeys by a sensitizing regimen of dopamine D1 receptor stimulation." J Neurosci 24, no. 6 (2004): 1446-50. Knopman, D. S., B. F. Boeve, and R. C. Petersen. "Essentials of the proper diagnoses of mild cognitive impairment, dementia, and major subtypes of dementia." Mayo Clin Proc 78, no. 10 (2003): 1290-308.
	Final Exam