Readings

Course Overview/Clinical Problems for Tissue Engineering Solution

Introduction to Tissue Engineering in China

Scaffolds: Introduction
 

Scaffolds: Collagen-GAG Analogs of Extracellular Matrix

Liu, Wei, Lei Cui, and Yilin Cao. "A Closer View of Tissue Engineering in China: The Experience of Tissue Construction in Immunocompetent Animals." Tissue Engineering 9, Suppl. 1 (2003): S17-S30.

Xiang, Zhou, and Myron Spector. "A Glimpse of Tissue Engineering in China." Tissue Engineering 8, no. 2 (2002): 169-174.

Spector, M. "Novel Cell–Scaffold Interactions Encountered in Tissue Engineering: Contractile Behavior of Musculoskeletal Connective Tissue Cells." Tissue Engineering 8, no. 3 (2002): 351-357.

Chamberlain, Lila J., and Loannis V. Yannas. "Preparation of Collagen-Glycosaminoglycan Copolymers for Tissue Regeneration." Tissue Engineering Methods and Protocols. Vol. 18, Methods in Molecular Medicine. Edited by J. R. Morgan and M. L. Yarmush. Totowa, NJ: Humana Press Inc., 1998, pp. 3-17. ISBN: 9780896035164 .

Ellis, D. L., and I. V. Yannas. "Recent Advances in Tissue Synthesis in Vivo by use of Collagen-Glycosaminoglycan Copolymers." Biomaterials 17, no. 3 (1996): 291-299.

Yannas, Ioannis V. "Synthesis of Organs: In Vitro or in Vivo?" PNAS 97, no. 17 (August 15, 2000): 9354-9356.

Scaffolds: Free-Form Manufacturing

Scaffolds: Self-Assembled Proteins

Review

Curodeau, Alan, Emanuel Sachs, and Salvatore Caldarise. "Design and Fabrication of Cast Orthopedic Implants with Freeform Surface Textures from 3-D Printed Ceramic Shell." J. Biomed. Mater. Res. (Appl. Biomater.) 53 (2000): 525-535. (John Wiley & Sons, Inc.)

Yan, Yongnian, Zhuo Xiong, Yunyu Hu, Shenguo Wang, Renji Zhang, and Chao Zhang. "Layered Manufacturing of Tissue Engineering Scaffolds via Multi-Nozzle Deposition." Materials Letters 57 (2003): 2623–2628.

Xiong, Zhuo, Yongnian Yan, Shenguo Wang, Renji Zhang, and Chao Zhang. "Fabrication of Porous Scaffolds for Bone Tissue Engineering via Low-temperature Deposition." Scripta Materialia 46 (2002): 771–776.

Kisiday, J., M. Jin, B. Kurz, H. Hung, C. Semino, S. Zhang, and A. J. Grodzinsky. "Self-Assembling Peptide Hydrogel Fosters Chondrocyte Extracellular Matrix Production and Cell Division: Implications for Cartilage Tissue Repair." PNAS 99, no. 15 (July 23, 2002): 9996–10001.

Zhang, Shuguang, Todd C. Holmes, C. Michael DiPersio, Richard O. Hynes, Xing Su, and Alexander Rich. "Self-Complementary Oligopeptide Matrices Support Mammalian Cell Attachment." Biomaterials 16 (1995): 1385-1393.

Zhang, Shuguang, Davide M. Marini, Wonmuk Hwang, and Steve Santoso. "Design of Nanostructured Biological Materials through Self-Assembly of Peptides and Proteins." Current Opinion in Chemical Biology 6 (2002): 865–871.

Cells: Embryonic and Other Stem Cell for Tissue Engineering

Gene Therapy

Regulators: Gene Transfer Wedded to Tissue Engineering

Samuel, R. E., C. R. Lee, S. C. Ghivizzani, C. H. Evans, I. V. Yannas, B. R. Olsen, and M. Spector. "Delivery of Plasmid DNA to Articular Chondrocytes via Novel Collagen–Glycosaminoglycan Matrices." Human Gene Therapy 13 (May 1, 2002): 791–802.

Lieberman, Jay R., Steven C. Ghivizzani, and Christopher H. Evans. "Gene Transfer Approaches to the Healing of Bone and Cartilage." Molecular Therapy 6, no. 2, (August 2002): 141-147.

Applications: Skin and Peripheral Nerve

Nerve Repair

Discussion: Clinical Applications

Yannas, I. V., J. F. Burke, D. P. Orgill, and E. M. Skrabut. "Wound Tissue can Utilize a Polymeric Template to Synthesize a Functional Extension of Skin." Science 215, no. 4529 (January 8, 1982): 174-176. (New Series)

Yannas, I. V., E. Lee, D. P. Orgill, E. M. Skrabut, and G. F. Murphy. "Synthesis and Characterization of a Model Extracellular Matrix that Induces Partial Regeneration of Adult Mammalian Skin." Proceedings of the National Academy of Sciences of the United States of America 86, no. 3 (February 1, 1989): 933-937.

Yang, Fei, Xunhu Li, Mingyu Cheng, Yandao Gong, Nanming Zhao, Xiufang Zhang, and Yinye Yang. "Performance Modification of Chitosan Membranes Induced by Gamma Irradiation." Journal of Biomaterials Applications 00 (November 2001): 1-12.

Haipeng, Gong, Zhong Yinghui, Li Jianchun, Gong Yandao, Zhao Nanming, and Zhang Xiufang. "Studies on Nerve Cell Affinity of Chitosan-Derived Materials." J. Biomed. Mater. Res. 52 (2000): 285–295. (John Wiley & Sons, Inc.)

Cheng, Mingyu, Jinguang Deng, Fei Yang, Yandao Gong, Nanming Zhao, and Xiufang Zhang. "Study on Physical Properties and Nerve Cell Affinity of Composite Films from Chitosan and Gelatin Solutions." Biomaterials 24 (2003): 2871–2880.

Urinary Tissues/Organs

Clinical Applications and Underlying Principles

References (PDF)

De Filippo, Roger E., James J. Yoo, and Anthony Atala. "Urethral Replacement using Cell Seeded Tubularized Collagen Matrices." The Journal of Urology 168 (October 2002): 1789–1793.

———. "Engineering of Vaginal Tissue in Vivo." Tissue Engineering 9, no. 2 (2003): 301-306.

Liu, Yanchun, Fuguo Chen, Wei Liu, Lei Cui, Qingxin Shang, Wangyao Xia, Jian Wang, Yimin Cui, Guanghui Yang, Deli Liu, Juanjuan Wu, Rong Xu, Samuel D. Buonocore, and Yilin Cao. "Repairing Large Porcine Full-Thickness Defects of Articular Cartilage Using Autologous Chondrocyte-Engineered Cartilage." Tissue Engineering 8, no. 4 (2002): 709-721.

Mao, Jinshu, Liguo Zhao, Kang de Yao, Qingxin Shang, Guanghui Yang, and Yilin Cao. "Study of Novel Chitosan-gelatin Artificial Skin in Vitro." J. Biomed. Mater. Res. 64A (2003): 301–308. (Wiley Periodicals, Inc.)

Federal Regulatory Issues for Tissue Engineering Products in the U.S., China, and Other Countries

Brain Repair

Review